HYDROLYSIS OF NEOSTIGMINE BY PLASMA CHOLINESTERASE
نویسندگان
چکیده
منابع مشابه
Substance P hydrolysis by human serum cholinesterase.
Highly purified human serum cholinesterase (EC 3.1.1.8, also known as pseudocholinesterase and butyrylcholinesterase) had peptidase activity toward substance P. Digestion of substance P was monitored by high performance liquid chromatography, which separated three product peptides. The cleavages occurred sequentially. The first peptide to appear as Arg1-Pro2. The Km for this hydrolysis was 0.3 ...
متن کاملInhibition of the plasma cholinesterase variants by propranolol.
The inhibitory effect of (+/-) propranolol 1.69 x 10(-4)-1.69 x 10(-7) mol litre-1 on normal and atypical plasma cholinesterase variants was investigated. The atypical enzyme is less sensitive to inhibition by (+/-) propranolol or either of its enantiomorphs than the usual enzyme. Propranolol 8.45 x 10(-6) mol litre-1 was used as differential inhibitor of 643 plasma samples from individuals of ...
متن کاملPlasma cholinesterase and malignant hyperthermia.
Sir,—Humphrey, Downing and Brock-Utne (1980) are less than accurate in describing the destiny of expiration switched to inspiration in the Johannesburg Circuit. They vaguely refer to experimental evidence gathered "while studying a similar system"—evidence which simply does not tally with known pharmacokinetic principles. With a fresh gas inflow of 70mlkg~' min"' in a patient weighing 65 kg, th...
متن کاملInfluence of ketamine on human plasma cholinesterase.
The influence of ketamine upon human plasma cholinesterase (E.C. 3.1.1.8) was determined by means of a colorimetric assay technique at 25 degrees C, pH 7.7 with butyrylthiocholine as substrate. Ketamine caused a reversible inhibition of cholinesterase (pI50= 2.75; apparent Ki=4.94X10(-4) M). The kinetic analysis of the inhibitory action revealed a mixed competitive/non-competitive type of mecha...
متن کاملStability of Cholinesterase in Frozen Plasma.
Specimens of plasma from 51 agricultural workers were divided into several portions for freezing and storage. Periodic assays (in duplicate) for cholinesterase activity in each specimen were compared with the initial values obtained on each fresh, unfrozen specimen. Freezing and/or thawing results in loss of approximately 30% of the plasma cholinesterase activity. It is not possible to use divi...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: British Journal of Pharmacology and Chemotherapy
سال: 1962
ISSN: 0366-0826
DOI: 10.1111/j.1476-5381.1962.tb01454.x